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The FDA explains that GLP-1 receptor agonists mimic the effects of a natural hormone released by the intestine, help lower blood sugar after eating, and act on brain regions involved in appetite and food intake
Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GLP-1 - Glucagon-like peptide-1 OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Mounjaro) - marketed for diabetes Tirzepatide (Zepbound) - marketed for weight loss MECHANISM OF ACTION GLP-1 and GIP GLP-1 stands for "glucagon-like peptide-1," and GIP stands for "glucose-dependent insulinotropic polypeptide." GIP is also sometimes referred to as "gastric inhibitory polypeptide." GLP-1 and GIP are hormones secreted by specialized cells in the small intestine in response to food consumption
52 Meal Patterns: Smaller, more frequent meals may be easier on the digestive system for both issues
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Age, baseline metabolic rate, concurrent medications, and lifestyle factors also influence results
Patients taking other glucose-lowering agents may experience more rapid glycemic improvements, though this must be balanced against increased hypoglycemia risk when combined with insulin or sulfonylureas
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